Publications

2021

Holthaus D., M.R. Kraft, S.M. Krug, S. Wolf, A. Müller, E.D. Betancourt, M. Schorr, G. Holland, F. Knauf, J.D. Schulzke, T. Äbischer, and C. Klotz
Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis.
Gastroenterology. In Press.
doi: 10.1053/j.gastro.2021.11.022.

Witkowski M., C. Tizian, M. Ferreira-Gomez, D. Niemeyer, T.C. Jones, F. Heinrich, S. Frischbutter, S. Angermair, T.  Hohnstein, I. Mattiola, P. Nawrath, S. McEwen, S. Zocche, E. Viviano, G.A. Heinz, M. Maurer, U. Kölsch, R.L. Chua, T. Aschman, C. Meisel, J. Radke, B. Sawitzki, J. Röhmel, K. Allers, V. Moos, T. Schneider, L. Hanitsch, M.A. Mall, C. Conrad, H. Radbruch, C.U. Dürr, J.A. Trapani, E. Marcenaro, T. Kallinich, V.M. Corman, F. Kurth, L.E. Sander, C. Drosten, S. Treskatsch, P. Durek, A. Kruglov, A. Radbruch, M.F. Mashreghi, and A. Diefenbach
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. In Press.
doi: 10.1038/s41586-021-04142-6.

Stehle, C., T. Rückert, R. Fiancette, D.W. Gajdasik, C. Willis, C. Ulbricht, P. Durek, M.F. Mashreghi, D. Finke, A.E. Hauser, D.R. Withers, H.D. Chang, J. Zimmermann, and C. Romagnani
T-bet and RORα control lymph node formation by regulating embryonic innate lymphoid cell differentiation
Nature Immunology. 22(10):1231-1244.
doi: 10.1038/s41590-021-01029-6.

Haghikia, A., F. Zimmermann, P. Schumann, A. Jasina, J. Roessler, D. Schmidt, P. Heinze, J. Kaisler, V. Nageswaran, A. Aigner, U. Ceglarek, R. Cineus, A.N. Hegazy, E.P.C. van der Vorst, Y. Döring, C.M. Strauch, I. Nemet, V. Tremaroli, C. Dwibedi, N. Kränkel, D.M. Leistner, M.M. Heimesaat, S. Bereswill, G. Rauch, U. Seeland, O. Soehnlein, D.N. Müller, R. Gold, F. Bäckhed, S.L. Hazen, and U. Landmesser.
Propionate attenuates atherosclerosis by immune-dependent regulation of intestinal cholesterol metabolism.
Eur Heart J. ehab644.
doi: 10.1093/eurheartj/ehab644.

Lang-Schwarz, C., M. Angeloni, A. Agaimy, R. Atreya, C. Becker, T. Dregelies, S. Danese, J.F. Fléjou, N. Gaßler, H.I. Grabsch, A. Hartmann, K. Kamarádová, A.A. Kühl, G.Y. Lauwers, A. Lugli, I. Nagtegaal, M.F. Neurath, G. Oberhuber, L. Peyrin-Biroulet, T. Rath, R. Riddell, C.A. Rubio, K. Sheahan , B. Siegmund, H. Tilg, V. Villanacci, M. Westerhoff, F. Ferrazzi, and M. Vieth.
Validation of the ‚Inflammatory Bowel Disease-Distribution, Chronicity, Activity [IBD-DCA] Score‘ for Ulcerative Colitis and Crohn´s Disease.
J Crohns Colitis. 15(10):1621-1630.
doi: 10.1093/ecco- jcc/jjab055.

Acera, M.G., M. Bubeck, F. Mascia, L. Diemand, G. Sturm, A.A. Kühl, R. Atreya, D.C. Lie, M.F. Neurath, M. Schumann, C.S.N. Klose, Z. Trajanoski, C. Becker, and J.V. Patankar.
Dynamic, Transient, and Robust Increase in the Innervation of the Inflamed Mucosa in Inflammatory Bowel Diseases.
Cells 10(9):2253
doi: 10.3390/cells10092253

Acera, M.G., J.V. Patankar, L. Diemand, B. Siegmund, M.F. Neurath, S. Wirtz, and C. Becker.
Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype.
Frontiers in Medicine 8:664045.
doi: 10.3389/fmed.2021.664045

Ackermann, M., H.J. Anders, R. Bilyy, G.L. Bowlin, C. Daniel, R. De Lorenzo, M. Egeblad, T. Henneck, A. Hidalgo, M. Hoffmann, B. Hohberger, Y. Kanthi, M.J. Kaplan, J.S. Knight, J. Knopf, E. Kolaczkowska, P. Kubes, M. Leppkes, A. Mahajan, A.A. Manfredi, C. Maueroder, N. Maugeri, I. Mitroulis, L.E. Munoz, T. Narasaraju, E. Naschberger, I. Neeli, L.G. Ng, M.Z. Radic, K. Ritis, P. Rovere-Querini, M. Schapher, C. Schauer, H.U. Simon, J. Singh, P. Skendros, K. Stark, M. Sturzl, J. van der Vlag, P. Vandenabeele, L. Vitkov, M. von Kockritz-Blickwede, C. Yanginlar, S. Yousefi, A. Zarbock, G. Schett, and M. Herrmann.
Patients with COVID-19: in the dark-NETs of neutrophils.
Cell Death and Differentiation 28(11):3125-3139.
doi: 10.1038/s41418-021-00805-z.

Anchang, C.G., C. Xu, M.G. Raimondo, R. Atreya, A. Maier, G. Schett, V. Zaburdaev, S. Rauber, and A. Ramming.
The Potential of OMICs Technologies for the Treatment of Immune-Mediated Inflammatory Diseases.
International Journal of Molecular Sciences 22(14):7506.
doi: 10.3390/ijms22147506.

Atreya, R., and M.F. Neurath.
Can Serum Proteomic Profiling Annunciate Individual Disease Progression in Newly Diagnosed Inflammatory Bowel Disease Patients?
Journal of Crohns & Colitis 15(5):697-698.
doi: 10.1093/ecco-jcc/jjab009.

Atreya, R., and B. Siegmund.
Location is important: differentiation between ileal and colonic Crohn’s disease.
Nature Reviews Gastroenterology & Hepatology 18(8):544-558.
doi: 10.1038/s41575-021-00424-6.

Bittel, M., P. Reichert, I. Sarfati, A. Dressel, S. Leikam, S. Uderhardt, I. Stolzer, T.A. Phu, M. Ng, N.K. Vu, S. Tenzer, U. Distler, S. Wirtz, V. Rothhammer, M.F. Neurath, R.L. Raffai, C. Günther, and S. Momma.
Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo.
Journal of Extracellular Vesicles 10(12):e12159.
doi: 10.1002/jev2.12159.

Bojarski, C., M. Waldner, T. Rath, S. Schürmann, M.F.F. Neurath, R. Atreya, and B. Siegmund.
Innovative Diagnostic Endoscopy in Inflammatory Bowel Diseases: From High-Definition to Molecular Endoscopy.
Frontiers in Medicine 8:655404.
doi: 10.3389/fmed.2021.655404.

Buchbender, M., J. Fehlhofer, P. Proff, T. Most, J. Ries, M. Hannig, M.F. Neurath, M. Gund, R. Atreya, and M. Kesting.
Expression of inflammatory mediators in biofilm samples and clinical association in inflammatory bowel disease patients-a preliminary study.
Clinical Oral Investigations
doi: 10.1007/s00784-021-04093-2.

Buchele, V., P. Konein, T. Vogler, T. Kunert, K. Enderle, H. Khan, M. Buttner-Herold, C.H.K. Lehmann, L. Amon, S. Wirtz, D. Dudziak, M.F. Neurath, C. Neufert, and K. Hildner.
Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner.
Frontiers in Immunology 11:590893.
doi: 10.3389/fimmu.2020.590893.

Delbue, D., L. Lebenheim, D. Cardoso-Silva, V. Dony, S.M. Krug, J.F. Richter, S. Manna, M. Munoz, K. Wolk, C. Heldt, M.M. Heimesaat, R. Sabat, B. Siegmund, and M. Schumann.
Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22.
Frontiers in Medicine 8:656047.
doi: 10.3389/fmed.2021.656047.

Drobny, A., P.A. Ngo, M.F. Neurath, F. Zunke, and R. Lopez-Posadas.
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson’s Disease.
Frontiers in Medicine 8:655123.
doi: 10.3389/fmed.2021.655123.

Enderle, K., M. Dinkel, E.M. Spath, B. Schmid, S. Zundler, P. Tripal, M.F. Neurath, K. Hildner, and C. Neufert.
Dynamic Imaging of IEL-IEC Co-Cultures Allows for Quantification of CD103-Dependent T Cell Migration.
International Journal of Molecular Sciences 22(10):5148.
doi: 10.3390/ijms22105148.

Ferreira-Gomes, M., A. Kruglov, P. Durek, F. Heinrich, C. Tizian, G.A. Heinz, A. Pascual-Reguant, W.J. Du, R. Mothes, C.F. Fan, S. Frischbutter, K. Habenicht, L. Budzinski, J. Ninnemann, P.K. Jani, G.M. Guerra, K. Lehmann, M. Matz, L. Ostendorf, L. Heiberger, H.D. Chang, S. Bauherr, M. Maurer, G. Schonrich, M. Raftery, T. Kallinich, M.A. Mall, S. Angermair, S. Treskatsch, T. Dorner, V.M. Corman, A. Diefenbach, H.D. Volk, S. Elezkurtaj, T.H. Winkler, J. Dong, A.E. Hauser, H. Radbruch, M. Witkowski, F. Melchers, A. Radbruch, and M.F. Mashreghi.
SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself.
Nature Communications 12(1):1961.
doi: 10.1038/s41467-021-22210-3.

Fischer, S., S. Cohnen, E. Klenske, H. Schmitt, F. Vitali, S. Hirschmann, A. Ramming, S. Zundler, T. Rath, S. Krebs, F. Dorje, W. Uter, D. Nagore, S. Meyer, M.F. Neurath, and R. Atreya.
Long-term effectiveness, safety and immunogenicity of the biosimilar SB2 in inflammatory bowel disease patients after switching from originator infliximab.
Therapeutic Advances in Gastroenterology 14:1756284820982802.
doi: 10.1177/1756284820982802.

Gerbeth, L., B. Siegmund, and R. Glauben.
Histone Deacetylases in the Inflamed Intestinal Epithelium-Promises of New Therapeutic Strategies.
Frontiers in Medicine 8:655956.
doi: 10.3389/fmed.2021.655956.

Günther, C., V. Rothhammer, M. Karow, M. Neurath, and B. Winner.
The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives.
International Journal of Molecular Sciences 22(16):8870.
doi: 10.3390/ijms22168870.

Hernandez, D.C., K. Juelke, N.C. Muller, P. Durek, B. Ugursu, M.F. Mashreghi, T. Ruckert, and C. Romagnani.
An in vitro platform supports generation of human innate lymphoid cells from CD34(+) hematopoietic progenitors that recapitulate ex vivo identity.
Immunity 54(10):2417-2432.e5.
doi: 10.1016/j.immuni.2021.07.019.

Hirschmann, S., S. Fischer, E. Klenske, K. Dechant, J.H.W. Distler, C. Treutlein, M.F. Neurath, and R. Atreya.
Case report of severe constrictive perimyocarditis and ischemic hepatitis in a Crohn’s disease patient upon infliximab-induced lupus-like syndrome.
Therapeutic Advances in Gastroenterology 14:17562848211044033.
doi: 10.1177/17562848211044033.

Hosari, D., S. Hosari, A. Mahajan, L. Oreski, J. Schoen, X. Shan, J. Singh, H. Wang, K.O. Yaykasli, J. Knopf, L.E. Munoz, C. Schauer, and M. Herrmann.
NEUTROPHILS AND NETS AS ORCHESTRATORS OF INFLAMMATORY DISEASES.
Clinical and Experimental Rheumatology 39:1151-1152.

Hu, J.C.E., F. Weiss, C. Bojarski, F. Branchi, J.D. Schulzke, M. Fromm, and S.M. Krug.
Expression of tricellular tight junction proteins and the paracellular macromolecule barrier are recovered in remission of ulcerative colitis.
Bmc Gastroenterology 21(1):141
doi: 10.1186/s12876-021-01723-7.

Jackson, M.A., C. Pearson, N.E. Ilott, K.E. Huus, A.N. Hegazy, J. Webber, B.B. Finlay, A.J. Macpherson, F. Powrie, and L.H. Lam.
Accurate identification and quantification of commensal microbiota bound by host immunoglobulins.
Microbiome 9(1):33.
doi: 10.1186/s40168-020-00992-w.

Jefremow, A., and M.F. Neurath.
SARS-CoV-2 Virus Manifestations in the Gastrointestinal Tract: Therapeutic Implications.
Visceral Medicine 37(1):63-69.
doi: 10.1159/000513180.

Jessen, B., Y. Rodriguez-Sillke, E. Sonnenberg, M. Schumann, A. Kruglov, I. Freise, F. Schmidt, J. Maul, A.A. Kühl, R. Glauben, D. Lissner, and B. Siegmund.
Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can Be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab.
Clinical Gastroenterology and Hepatology 19(4):721-731.
doi: 10.1016/j.cgh.2020.03.066.

Kang, L., A. Schmalzl, T. Leupold, M. Gonzalez-Acera, R. Atreya, M.F. Neurath, C. Becker, and S. Wirtz.
CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis.
Frontiers in Immunology 11:609400.
doi: 10.3389/fimmu.2020.609400.

Katkeviciute, E., L. Hering, A. Montalban-Arques, P. Busenhart, M. Schwarzfischer, R. Manzini, J. Conde, K. Atrott, S. Lang, G. Rogler, E. Naschberger, V.S. Schellerer, M. Stürzl, A. Rickenbacher, M. Turina, A. Weber, S. Leibl, G.E. Leventhal, M. Levesque, O. Boyman, M. Scharl, and M.R. Spalinger.
Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development.
Journal of Clinical Investigation 131(1):e140281.
doi: 10.1172/JCI140281.

Lang-Schwarz, C., A. Agaimy, R. Atreya, C. Becker, S. Danese, J.F. Flejou, N. Gassler, H.I. Grabsch, A. Hartmann, K. Kamaradova, A.A. Kühl, G.Y. Lauwers, A. Lugli, I. Nagtegaal, M.F. Neurath, G. Oberhuber, L. Peyrin-Biroulet, T. Rath, R. Riddell, C.A. Rubio, K. Sheahan, H. Tilg, V. Villanacci, M. Westerhoff, and M. Vieth.
Maximizing the diagnostic information from biopsies in chronic inflammatory bowel diseases: recommendations from the Erlangen International Consensus Conference on Inflammatory Bowel Diseases and presentation of the IBD-DCA score as a proposal for a new index for histologic activity assessment in ulcerative colitis and Crohn’s disease.
Virchows Archiv 478(3):581-594.
doi: 10.1007/s00428-020-02982-7.

Lechner, K., S. Mott, R. Al-Saifi, L. Knipfer, S. Wirtz, R. Atreya, M. Vieth, T. Rath, T. Fraass, Z. Winter, A. August, J. Luban, V.S. Zimmermann, B. Weigmann, and M.F. Neurath.
Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis.
Gastroenterology 161(4):1270-1287.

Lehmann, M., K. Allers, C. Heldt, J. Meinhardt, F. Schmidt, Y. Rodriguez-Sillke, D. Kunkel, M. Schumann, C. Bottcher, C. Stahl-Hennig, S. Elezkurtaj, C. Bojarski, H. Radbruch, V.M. Corman, T. Schneider, C. Loddenkemper, V. Moos, C. Weidinger, A.A. Kühl, and B. Siegmund.
Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8(+) T cells.
Mucosal Immunology 14(6):1381-1392.
doi: 10.1038/s41385-021-00437-z.

Mahajan, A., L. Hasikova, U. Hampel, A. Gruneboom, X.M. Shan, I. Herrmann, F. Garreis, F. Bock, J. Knopf, J. Singh, C. Schauer, S. Mahajan, M. Leppkes, F. Paulsen, U. Schlotzer-Schrehardt, V. Krenn, A. Junemann, B. Hohberger, G. Schett, M. Herrmann, and L.E. Munoz.
Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation.
Ocular Surface 20:1-12.
doi: 10.1016/j.jtos.2020.12.005.

Mahapatro, M., L. Erkert, and C. Becker.
Cytokine-Mediated Crosstalk between Immune Cells and Epithelial Cells in the Gut.
Cells 10(1):111.
doi: 10.3390/cells10010111.

Maschmeyer, P., H.D. Chang, Q.Y. Cheng, M.F. Mashreghi, F. Hiepe, T. Alexander, and A. Radbruch.
Immunological memory in rheumatic inflammation – a roadblock to tolerance induction.
Nature Reviews Rheumatology 17(5):291-305.
doi: 10.1038/s41584-021-00601-6.

Meinhardt, J., J. Radke, C. Dittmayer, J. Franz, C. Thomas, R. Mothes, M. Laue, J. Schneider, S. Brunink, S. Greuel, M. Lehmann, O. Hassan, T. Aschman, E. Schumann, R.L. Chua, C. Conrad, R. Eils, W. Stenzel, M. Windgassen, L. Rossler, H.H. Goebel, H.R. Gelderblom, H. Martin, A. Nitsche, W.J. Schulz-Schaeffer, S. Hakroush, M.S. Winkler, B. Tampe, F. Scheibe, P. Kortvelyessy, D. Reinhold, B. Siegmund, A.A. Kühl, S. Elezkurtaj, D. Horst, L. Oesterhelweg, M. Tsokos, B. Ingold-Heppner, C. Stadelmann, C. Drosten, V.M. Corman, H. Radbruch, and F.L. Heppner.
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.
Nature Neuroscience 24(2):168-175.
doi: 10.1038/s41593-020-00758-5.

Muhl, L., E. Becker, T.M. Muller, R. Atreya, I. Atreya, M.F. Neurath, and S. Zundler.
Clinical experiences and predictors of success of treatment with vedolizumab in IBD patients: a cohort study.
Bmc Gastroenterology 21(1):33.
doi: 10.1186/s12876-021-01604-z.

Munoz, M., A.N. Hegazy, T.M. Brunner, V. Holecska, R.M. Marek, A. Frohlich, and M. Lohning.
Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10.
Proceedings of the National Academy of Sciences of the United States of America 118(6):e2002787118.
doi: 10.1073/pnas.2002787118.

Neufert, C., C. Heichler, T. Brabletz, K. Scheibe, V. Boonsanay, F.R. Greten, and M.F. Neurath.
Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis.
Nature Protocols 16(1):61-85.
doi: 10.1038/s41596-020-00412-1.

Neurath, M.F.
COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology.
Nature Reviews Gastroenterology & Hepatology 18(10):705-715.
doi: 10.1038/s41575-021-00480-y.

Neurath, M.F., K. Uberla, and S.C. Ng.
Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19.
Gut 70(9):1605-1608.
doi: 10.1136/gutjnl-2021-324622.

Patankar, J.V., M.T. Chiriac, M. Lehmann, A.A. Kühl, R. Atreya, and C. Becker.
Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn’s Disease and Regulated By Microbial and Inflammatory Signaling.
Gastroenterology 160(3):925-928.e4.
doi: 10.1053/j.gastro.2020.10.021.

Patankar, J.V., T.M. Muller, S. Kantham, M.G. Acera, F. Mascia, K. Scheibe, M. Mahapatro, C. Heichler, Y.Q. Yu, W. Li, B. Ruder, C. Günther, M. Leppkes, M.J. Mathew, S. Wirtz, C. Neufert, A.A. Kühl, J. Paquette, K. Jacobson, R. Atreya, S. Zundler, M.F. Neurath, R.N. Young, and C. Becker.
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Nature Cell Biology 23(7):796-807.
doi: 10.1038/s41556-021-00708-8.

Pradhan, R., P.A. Ngo, L.D.C. Martinez-Sanchez, M.F. Neurath, and R. Lopez-Posadas.
Rho GTPases as Key Molecular Players within Intestinal Mucosa and GI Diseases.
Cells 10(1):66.
doi: 10.3390/cells10010066.

Regensburger, D., C. Tenkerian, V. Purzer, B. Schmid, T. Wohlfahrt, I. Stolzer, R. Lopez-Posadas, C. Günther, M.J. Waldner, C. Becker, H. Sticht, K. Petter, C. Flierl, T. Gass, T. Thoenissen, C.I. Geppert, N. Britzen-Laurent, V.S. Meniel, A. Ramming, M. Stürzl, and E. Naschberger.
Matricellular Protein SPARCL1 Regulates Blood Vessel Integrity and Antagonizes Inflammatory Bowel Disease.
Inflammatory Bowel Diseases 27(9):1491-1502.
doi: 10.1093/ibd/izaa346.

Rincon-Arevalo, H., M. Choi, A.L. Stefanski, F. Halleck, U. Weber, F. Szelinski, B. Jahrsdorfer, H. Schrezenmeier, C. Ludwig, A. Sattler, K. Kotsch, A. Potekhin, Y.D. Chen, G.R. Burmester, K.U. Eckardt, G.M. Guerra, P. Durek, F. Heinrich, M. Ferreira-Gomes, A. Radbruch, K. Budde, A.C. Lino, M.F. Mashreghi, E. Schrezenmeier, and T. Dorner.
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.
Science Immunology 6(60):eabj1031.
doi: 10.1126/sciimmunol.abj1031.

Schmitt, H., M.F. Neurath, and R. Atreya.
Role of the IL23/IL17 Pathway in Crohn’s Disease.
Frontiers in Immunology 12:622934.
doi: 10.3389/fimmu.2021.622934.

Schulz-Kuhnt, A., M.F. Neurath, S. Wirtz, and I. Atreya.
Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases.
Frontiers in Medicine 8:656745.
doi: 10.3389/fmed.2021.656745.

Seiwert, N., J. Adam, P. Steinberg, S. Wirtz, T. Schwerdtle, P. Adams-Quack, N. Hovelmeyer, B. Kaina, S. Foersch, and J. Fahrer.
Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo.
Archives of Toxicology 95(7):2507-2522.
doi: 10.1007/s00204-021-03064-6.

Semin, I., J. Ninnemann, M. Bondareva, I. Gimaev, and A.A. Kruglov.
Interplay Between Microbiota, Toll-Like Receptors and Cytokines for the Maintenance of Epithelial Barrier Integrity.
Frontiers in Medicine 8:644333.
doi: 10.3389/fmed.2021.644333.

Sommer, K., M. Wiendl, T.M. Muller, K. Heidbreder, C. Voskens, M.F. Neurath, and S. Zundler.
Intestinal Mucosal Wound Healing and Barrier Integrity in IBD-Crosstalk and Trafficking of Cellular Players.
Frontiers in Medicine 8:643973.
doi: 10.3389/fmed.2021.643973.

Song, W.P., J. Ye, N.F. Pan, C.Y. Tan, and M. Herrmann.
Neutrophil Extracellular Traps Tied to Rheumatoid Arthritis: Points to Ponder.
Frontiers in Immunology 11:578129.
doi: 10.3389/fimmu.2020.578129.

Stolzer, I., A. Dressel, M.T. Chiriac, M.F. Neurath, and C. Günther.
An IFN-STAT Axis Augments Tissue Damage and Inflammation in a Mouse Model of Crohn’s Disease.
Frontiers in Medicine 8:644244.
doi: 10.3389/fmed.2021.644244.

Stolzer, I., B. Ruder, M.F. Neurath, and C. Günther.
Interferons at the crossroad of cell death pathways during gastrointestinal inflammation and infection.
International Journal of Medical Microbiology 311(3):151491
doi: 10.1016/j.ijmm.2021.151491.

Stolzer, I., L. Schickedanz, M.T. Chiriac, R. Lopez-Posadas, G.A. Grassl, J. Mattner, S. Wirtz, B. Winner, M.F. Neurath, and C. Günther.
STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8.
Mucosal Immunology
doi: 10.1038/s41385-021-00450-2.

Stürzl, M., M. Kunz, S.M. Krug, and E. Naschberger.
Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease.
Frontiers in Medicine 8:643607.
doi: 10.3389/fmed.2021.643607.

Wagner, A.L., V. Danko, A. Federle, D. Klett, D. Simon, R. Heiss, J. Jungert, M. Uder, G. Schett, M.F. Neurath, J. Woelfle, M.J. Waldner, R. Trollmann, A.P. Regensburger, and F. Knieling.
Precision of handheld multispectral optoacoustic tomography for muscle imaging.
Photoacoustics 21:100220.
doi: 10.1016/j.pacs.2020.100220.

Weidinger, C., A.N. Hegazy, R. Glauben, and B. Siegmund.
COVID-19-from mucosal immunology to IBD patients.
Mucosal Immunology 14(3):566-573.
doi: 10.1038/s41385-021-00384-9.

Wiendl, M., E. Becker, T.M. Muller, C.J. Voskens, M.F. Neurath, and S. Zundler.
Targeting Immune Cell Trafficking – Insights From Research Models and Implications for Future IBD Therapy.
Frontiers in Immunology 12:656452.
doi: 10.3389/fimmu.2021.656452.

Wirtz, S., A. Schulz-Kuhnt, M.F. Neurath, and I. Atreya.
Functional Contribution and Targeted Migration of Group-2 Innate Lymphoid Cells in Inflammatory Lung Diseases: Being at the Right Place at the Right Time.
Frontiers in Immunology 12:688879.
doi: 10.3389/fimmu.2021.688879.

Zimmermann, T., L.A. Gebhardt, L. Kreiss, C. Schneider, S. Arndt, S. Karrer, O. Friedrich, M.J.M. Fischer, and A.K. Bosserhoff.
Acidified Nitrite Contributes to the Antitumor Effect of Cold Atmospheric Plasma on Melanoma Cells.
International Journal of Molecular Sciences 22(7):3757.
doi: 10.3390/ijms22073757.

Berte, R., S. Mazza, M.R. Stefanucci, D. Noviello, S. Costa, C. Ciafardini, E. Mileti, M. Mapelli, S. Pasqualato, S. Pinto, A. Favale, M. Vecchi, M.F. Neurath, R. Atreya, M.C. Fantini, F. Facciotti, and F. Caprioli.
Seroprevalence of SARS-CoV2 in IBD Patients Treated with Biologic Therapy.
Journal of Crohns & Colitis 15(5):864-868.
doi: 10.1093/ecco-jcc/jjaa237.

2020

Breidert M., P. Eftekhari, F. Louis, C. Rotoiu, T. Rath, M.F. Neurath, and R. Atreya
Functional Molecular Network Analysis Enables Prediction of Response to Vedolizumab Therapy in Anti-TNF Refractory IBD Patients.
Crohns Colitis 360. 2020 Apr;2(2):otaa037.
doi: 10.1093/crocol/otaa037.

Abdullah, A., M.F. Neurath, and R. Atreya.
Mild COVID-19 Symptoms in an Infliximab-Treated Ulcerative Colitis Patient: Can Ongoing Anti-TNF Therapy Protect against the Viral Hyperinflammatory Response and Avoid Aggravated Outcomes?
Visceral Medicine 36(4):338-342.
doi: 10.1159/000508740.

Alliger, K., M. Khalil, B. Konig, S. Weisenburger, E. Koch, and M. Engel.
Menthacarin attenuates experimental colitis.
Phytomedicine 77:153212
doi: 10.1016/j.phymed.2020.153212.

Atreya, R., M.F. Neurath, and B. Siegmund.
Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF?
Frontiers in Medicine 7:517
doi: 10.3389/fmed.2020.00517.

Atreya, R., L. Peyrin-Biroulet, A. Klymenko, M. Augustyn, I. Bakulin, D. Slankamenac, P. Miheller, A. Gasbarrini, X. Hebuterne, K. Arnesson, T. Knittel, J. Kowalski, M.F. Neurath, W.J. Sandborn, W. Reinisch, and C.S. Grp.
Cobitolimod for moderate-to-severe, left-sided ulcerative colitis (CONDUCT): a phase 2b randomised, double-blind, placebo-controlled, dose-ranging induction trial.
Lancet Gastroenterology & Hepatology 5(12):1063-1075.
doi: 10.1016/S2468-1253(20)30301-0.

Babic, M., C. Dimitropoulos, Q. Hammer, C. Stehle, F. Heinrich, A. Sarsenbayeva, A. Eisele, P. Durek, M.F. Mashreghi, B. Lisnic, J. Van Snick, M. Lohning, S. Fillatreau, D.R. Withers, N. Gagliani, S. Huber, R.A. Flavell, B. Polic, and C. Romagnani. 
NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells.
Journal of Experimental Medicine 217(8):e20190133.
doi: 10.1084/jem.20190133.

Bardenbacher, M., B. Ruder, N. Britzen-Laurent, E. Naschberger, C. Becker, R. Palmisano, M. Stürzl, and P. Tripal.
Investigating Intestinal Barrier Breakdown in Living Organoids.
Jove-Journal of Visualized Experiments (157).
doi: 10.3791/60546.

Beller, A., A. Kruglov, P. Durek, V. von Goetze, K. Werner, G.A. Heinz, J. Ninnemann, K. Lehmann, R. Maier, U. Hoffmann, R. Riedel, K. Heiking, J. Zimmermann, B. Siegmund, M.F. Mashreghi, A. Radbruch, and H.D. Chang.
Specific microbiota enhances intestinal IgA levels by inducing TGF-beta in T follicular helper cells of Peyer’s patches in mice.
European Journal of Immunology 50(6):783-794.
doi: 10.1002/eji.201948474.

Carbotti, G., A. Petretto, E. Naschberger, M. Stürzl, S. Martini, M.C. Mingari, G. Filaci, S. Ferrini, and M. Fabbi.
Cytokine-Induced Guanylate Binding Protein 1 (GBP1) Release from Human Ovarian Cancer Cells.
Cancers 12(2):488
doi: 10.3390/cancers12020488.

Cosma-Grigorov, A., H. Meixner, A. Mrochen, S. Wirtz, J. Winkler, and F. Marxreiter.
Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates.
Frontiers in Neurology
11:1041.
doi: 10.3389/fneur.2020.01041.

Diefenbach, A., S. Gnafakis, and O. Shomrat.
Innate Lymphoid Cell-Epithelial Cell Modules Sustain Intestinal Homeostasis.
Immunity 52(3):452-463.
doi: 10.1016/j.immuni.2020.02.016.

Digby-Bell, J.L., R. Atreya, G. Monteleone, and N. Powell.
Interrogating host immunity to predict treatment response in inflammatory bowel disease.
Nature Reviews Gastroenterology & Hepatology 17(1):9-20.
doi: 10.1038/s41575-019-0228-5.

Gamez-Belmonte, R., L. Erkert, S. Wirtz, and C. Becker.
The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses.
International Journal of Molecular Sciences 21(24):9772.
doi: 10.3390/ijms21249772.

Ganzleben, I., S. Hirschmann, J. Kohler, F.S. Fuchs, R.J. Rieker, E. Baer, E. Klenske, D. Nagore, M.F. Neurath, and R. Atreya.
Successful Therapy of Crohn’s Disease-Associated Pulmonary Necrobiotic Nodules on Ustekinumab Therapy.
American Journal of Gastroenterology 115(4):632-634.
doi: 10.14309/ajg.0000000000000571.

Ganzleben, I., S. Hirschmann, A. Nagel, C. Gluck, T. Rath, M.F. Neurath, C. Gimped, L. Osaba, D. Nagore, A. Hoffman, and R. Atreya.
Successful cyclosporin and ustekinumab combination therapy in a patient with severe steroid-refractory ulcerative colitis.
Therapeutic Advances in Gastroenterology
13:1756284820954112.
doi: 10.1177/1756284820954112.

Ganzleben, I., M. Hohmann, A. Grunberg, J. Gonzales-Menezes, M. Vieth, E. Liebing, C. Günther, V. Thonn, D. Bess, C. Becker, M. Schmidt, M.F. Neurath, and M.J. Waldner.
Topical application of Chlorin e6-PVP (Ce6-PVP) for improved endoscopic detection of neoplastic lesions in a murine colitis-associated cancer model.
Scientific Reports 10(1):13129.
doi: 10.1038/s41598-020-69570-2.

Guendel, F., M. Kofoed-Branzk, K. Gronke, C. Tizian, M. Witkowski, H.W. Cheng, G.A. Heinz, F. Heinrich, P. Durek, P.S. Norris, C.F. Ware, C. Ruedl, S. Herold, K. Pfeffer, T. Hehlgans, A. Waisman, B. Becher, A.D. Giannou, S. Brachs, K. Ebert, Y. Tanriver, B. Ludewig, M.F. Mashreghi, A.A. Kruglov, and A. Diefenbach.
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Immunity 53(5):1015-1032.e8.
doi: 10.1016/j.immuni.2020.10.012.

Heichler, C., K. Scheibe, A. Schmied, C.I. Geppert, B. Schmid, S. Wirtz, O.M. Thoma, V. Kramer, M.J. Waldner, C. Buttner, H.F. Farin, M. Pesic, F. Knieling, S. Merkel, A. Gruneboom, M. Gunzer, R. Grutzmann, S. Rose-John, S.B. Koralov, G. Kollias, M. Vieth, A. Hartmann, F.R. Greten, M.F. Neurath, and C. Neufert.
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Gut 69(7):1269-1282.
doi: 10.1136/gutjnl-2019-319200.

Kempski, J., A.D. Giannou, K. Riecken, L.L. Zhao, B. Steglich, J. Lucke, L. Garcia-Perez, K.F. Karstens, A. Wostemeier, M. Nawrocki, P. Pelczar, M. Witkowski, S. Nilsson, L. Konczalla, A.M. Shiri, J. Kempska, R. Wahib, L. Brockmann, P. Huber, A.C. Gnirck, J.E. Turner, D.E. Zazara, P.C. Arck, A. Stein, R. Simon, A. Daubmann, J. Meiners, D. Perez, T. Strowig, P. Koni, A.A. Kruglov, G. Sauter, J.R. Izbicki, A.H. Guse, T. Rosch, A.W. Lohse, R.A. Flavell, N. Gagliani, and S. Huber.
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.
Gastroenterology 159(4):1417-1430.e3.
doi: 10.1053/j.gastro.2020.06.033.

Khalil, M., Z. Zhang, H. Abdel-Aziz, S. Rabini, R.M. Ammar, P.W. Reeh, and M.A. Engel.
Dual opposing actions of STW 5 on TRP receptors mediate neuronal desensitisation in vitro.
Life Sciences 257:118112.
doi: 10.1016/j.lfs.2020.118112.

Kindermann, M., L. Knipfer, S. Obermeyer, U. Muller, G. Alber, C. Bogdan, U. Schleicher, M.F. Neurath, and S. Wirtz.
Group 2 Innate Lymphoid Cells (ILC2) Suppress Beneficial Type 1 Immune Responses During Pulmonary Cryptococcosis.
Frontiers in Immunology 11:209.
doi: 10.3389/fimmu.2020.00209.

Klingler, A., D. Regensburger, C. Tenkerian, N. Britzen-Laurent, A. Hartmann, M. Stürzl, and E. Naschberger.
Species-, organ- and cell-type-dependent expression of SPARCL1 in human and mouse tissues.
Plos One 15(5):e0233422.
doi: 10.1371/journal.pone.0233422.

Kobayashi, T., B. Siegmund, C. Le Berre, S.C. Wei, M. Ferrante, B. Shen, C.N. Bernstein, S. Danese, L. Peyrin-Biroulet, and T. Hibi.
Ulcerative colitis.
Nature Reviews Disease Primers 6(1):74
doi: 10.1038/s41572-020-0205-x.

Kortekaas, K.E., S.J. Santegoets, G. Sturm, I. Ehsan, S.L. van Egmond, F. Finotello, Z. Trajanoski, M.J.P. Welters, M.I.E. van Poelgeest, and S.H. van der Burg.
CD39 Identifies the CD4(+) Tumor-Specific T-cell Population in Human Cancer.
Cancer Immunology Research 8(10):1311-1321.
doi: 10.1158/2326-6066.CIR-20-0270.

Kreiss, L., O.M. Thoma, A. Dilipkumar, B. Carle, P. Longequeue, T. Kunert, T. Rath, K. Hildner, C. Neufert, M. Vieth, M.F. Neurath, O. Friedrich, S. Schurmann, and M.J. Waldner.
Label-Free In Vivo Histopathology of Experimental Colitis via 3-Channel Multiphoton Endomicroscopy.
Gastroenterology 159(3):832-834.
doi: 10.1053/j.gastro.2020.05.081.

Krug, S.M., and M. Fromm.
Special Issue on „The Tight Junction and Its Proteins: More than Just a Barrier“.
International Journal of Molecular Sciences 21(13):4612.
doi: 10.3390/ijms21134612.

Krug, S.M., I.F.M. Lee, F. Weiss, J.C.E. Hu, M. Fromm, and J. Schulzke.
Impaired Tricellular Tight Junctions Open the Barrier for Lipopolysaccharide Uptake.
Faseb Journal 34(S1):1-1
doi: 10.1096/fasebj.2020.34.s1.03855

Kruglov, A., M. Drutskaya, D. Schlienz, E. Gorshkova, K. Kurz, L. Morawietz, and S. Nedospasov.
Contrasting contributions of TNF from distinct cellular sources in arthritis.
Annals of the Rheumatic Diseases 79(11):1453-1459.
doi: 10.1136/annrheumdis-2019-216068.

Leppkes, M., J. Knopl, E. Naschberger, A. Lindemann, J. Singh, I. Herrmann, M. Stürzl, L. Staats, A. Mahajan, C. Schauer, A.N. Kremer, S. Volkl, K. Amann, K. Evert, C. Falkies, A. Wehrfritz, R.J. Rieker, A. Hartmann, A.E. Kremer, M.F. Neurath, L.E. Munoz, G. Schett, and M. Herrmann.
Vascular occlusion by neutrophil extracellular traps in COVID-19.
Ebiomedicine 58:102925

Leppkes, M., and M.F. Neurath. 
Cytokines in inflammatory bowel diseases – Update 2020.
Pharmacological Research 158:104835
doi: 10.1016/j.phrs.2020.104835.

Martinez-Sanchez, L.D.C., R. Pradhan, P.A. Ngo, L. Erkert, L.S. Becker, A.J. Watson, I. Atreya, M.F. Neurath, and R. Lopez-Posadas.
An Intravital Microscopy-Based Approach to Assess Intestinal Permeability and Epithelial Cell Shedding Performance.
Jove-Journal of Visualized Experiments (166)
doi: 10.3791/60790.

Mayr, L., F. Grabherr, J. Schwrzler, I. Reitmeier, F. Sommer, T. Gehmacher, L. Niederreiter, G.W. He, B. Ruder, K.T.R. Kunz, P. Tymoszuk, R. Hilbe, D. Haschka, C. Feistritzer, R.R. Gerner, B. Enrich, N. Przysiecki, M. Seifert, M.A. Keller, G. Oberhuber, S. Sprung, Q.T. Ran, R. Koch, M. Effenberger, I. Tancevski, H. Zoller, A.R. Moschen, G. Weiss, C. Becker, P. Rosenstiel, A. Kaser, H. Tilg, and T.E. Adolph.
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease.
Nature Communications 11(1):1775.
doi: 10.1038/s41467-020-15646-6.

Mikuda, N., R. Schmidt-Ullrich, E. Kergel, L. Golusda, J. Wolf, U.E. Hpken, C. Scheidereit, A.A. Kühl, and M. Kolesnichenko.
Deficiency in I kappa B alpha in the intestinal epithelium leads to spontaneous inflammation and mediates apoptosis in the gut.
Journal of Pathology 251(2):160-174.
doi: 10.1002/path.5437.

Neufert, C., M.F. Neurath, and R. Atreya.
Rationale for IL-36 receptor antibodies in ulcerative colitis.
Expert Opinion on Biological Therapy 20(4):339-342.
doi: 10.1080/14712598.2020.1695775.

Neurath, M.F.
COVID-19 and immunomodulation in IBD.
Gut 69(7):1335-1342.
doi: 10.1136/gutjnl-2020-321269.

Patankar, J.V., and C. Becker.
Cell death in the gut epithelium and implications for chronic inflammation.
Nature Reviews Gastroenterology & Hepatology 17(9):543-556.
doi: 10.1038/s41575-020-0326-4.

Piontek, J., S.M. Krug, J. Protze, G. Krause, and M. Fromm.
Molecular architecture and assembly of the tight junction backbone.
Biochimica Et Biophysica Acta-Biomembranes 1862(7):183279.
doi: 10.1016/j.bbamem.2020.183279.

Ruder, B., and C. Becker.
At the Forefront of the Mucosal Barrier: The Role of Macrophages in the Intestine.
Cells 9(10):2162.
doi: 10.3390/cells9102162.

Ruder, B., C. Günther, M. Stürzl, M.F. Neurath, E. Cesarman, G. Ballon, and C. Becker.
Viral FLIP blocks Caspase-8 driven apoptosis in the gut in vivo.
Plos One
15(1):e0228441.
doi: 10.1371/journal.pone.0228441.

Schapher, M., M. Koch, D. Weidner, M. Scholz, S. Wirtz, A. Mahajan, I. Herrmann, J. Singh, J. Knopf, M. Leppkes, C. Schauer, A. Gruneboom, C. Alexiou, G. Schett, H. Iro, L.E. Munoz, and M. Herrmann.
Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones.
Cells 9(9):2139.
doi: 10.3390/cells9092139.

Schett, G., M. Sticherling, and M.F. Neurath.
COVID-19: risk for cytokine targeting in chronic inflammatory diseases?
Nature Reviews Immunology 20(5):271-272.
doi: 10.1038/s41577-020-0312-7.

Schleier, L., M. Wiendl, K. Heidbreder, M.T. Binder, R. Atreya, T. Rath, E. Becker, A. Schulz-Kuhnt, A. Stahl, L.L. Schulze, K. Ullrich, S.F. Merz, L. Bornemann, M. Gunzer, A.J.M. Watson, C. Neufert, I. Atreya, M.F. Neurath, and S. Zundler. 
Non-classical monocyte homing to the gut via alpha 4 beta 7 integrin mediates macrophage-dependent intestinal wound healing.
Gut 69(2):252-263.
doi: 10.1136/gutjnl-2018-316772.

Schmitt, H., J. Ulmschneider, U. Billmeier, M. Vieth, P. Scarozza, S. Sonnewald, S. Reid, I. Atreya, T. Rath, S. Zundler, M. Langheinrich, J. Schuttler, A. Hartmann, T. Winkler, C. Admyre, T. Knittel, C.D. Johansson, A. Zargari, M.F. Neurath, and R. Atreya.
The TLR9 Agonist Cobitolimod Induces IL10-Producing Wound Healing Macrophages and Regulatory T Cells in Ulcerative Colitis.
Journal of Crohns & Colitis 14(4):508-524.
doi: 10.1093/ecco-jcc/jjz170.

Schulz-Kuhnt, A., V. Greif, K. Hildner, L. Knipfer, M. Dobronti, S. Zirlik, F. Fuchs, R. Atreya, S. Zundler, R. Lopez-Posadas, C. Neufert, A. Ramming, A. Kiefer, A. Gruneboom, E. Strasser, S. Wirtz, M.F. Neurath, and I. Atreya.
ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure.
Frontiers in Immunology 11:691.
doi: 10.3389/fimmu.2020.00691.

Schulz-Kuhnt A., S. Wirtz, M.F. Neurath, and I. Atreya. 
Regulation of Human Innate Lymphoid Cells in the Context of Mucosal Inflammation.
Frontiers in Immunology 11:1062.
doi: 10.3389/fimmu.2020.01062.

Siegmund, B. 
Janus Kinase inhibitors in the New Treatment Paradigms of Inflammatory Bowel Disease.
Journal of Crohns & Colitis 14:S761-S766.
doi: 10.1093/ecco-jcc/jjaa003.

Sistemich, L., M. Kutsch, B. Hamisch, P. Zhang, S. Shydlovskyi, N. Britzen-Laurent, M. Stürzl, K. Huber, and C. Herrmann.
The Molecular Mechanism of Polymer Formation of Farnesylated Human Guanylate-binding Protein 1.
Journal of Molecular Biology 432(7):2164-2185.
doi: 10.1016/j.jmb.2020.02.009.

Staats, L.A.N., H. Pfeiffer, J. Knopf, A. Lindemann, J. Furst, A.E. Kremer, H. Hackstein, M.F. Neurath, L.E. Munoz, S. Achenbach, M. Leppkes, M. Herrmann, G. Schett, and U. Steffen.
IgA2 Antibodies against SARS-CoV-2 Correlate with NET Formation and Fatal Outcome in Severely Diseased COVID-19 Patients.
Cells 9(12):2676.
doi: 10.3390/cells9122676.

Stolzer, I., V. Kaden-Volynets, B. Ruder, M. Letizia, M. Bittel, P. Rausch, M. Basic, A. Bleich, J.F. Baines, M.F. Neurath, S. Wirtz, C. Weidinger, S.C. Bischoff, C. Becker, and C. Günther.
Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease-Like Inflammation.
Inflammatory Bowel Diseases 26(1):66-79.
doi: 10.1093/ibd/izz142.

Sturm, G., T. Szabo, G. Fotakis, M. Haider, D. Rieder, Z. Trajanoski, and F. Finotello.
Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data.
Bioinformatics 36(18):4817-4818.
doi: 10.1093/bioinformatics/btaa611.

Ullrich, K.A.M., L.L. Schulze, E.M. Paap, T.M. Muller, M.F. Neurath, and S. Zundler.
IMMUNOLOGY OF IL-12: AN UPDATE ON FUNCTIONAL ACTIVITIES AND IMPLICATIONS FOR DISEASE.
Excli Journal 19:1563-1589.
doi: 10.17179/excli2020-3104.

Werner, J.P.F., Y.H. Huang, K. Mishra, R. Janowski, P. Vetschera, C. Heichler, A. Chmyrov, C. Neufert, D. Niessing, V. Ntziachristos, and A.C. Stiel.
Challenging a Preconception: Optoacoustic Spectrum Differs from the Optical Absorption Spectrum of Proteins and Dyes for Molecular Imaging.
Analytical Chemistry 92(15):10717-10724.
doi: 10.1021/acs.analchem.0c01902.

Yu, Y.Q., M. Zielinska, W. Li, D.B. Bernkopf, C.S. Heilingloh, M.F. Neurath, and C. Becker.
PGAM5-MAVS interaction regulates TBK1/IRF3 dependent antiviral responses.
Scientific Reports 10(1):8323.
doi: 10.1038/s41598-020-65155-1.

Zundler, S., V. Tauschek, and M.F. Neurath.
Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications.
Visceral Medicine 36(2):129-136.
doi: 10.1159/000506846.

Heichler, C., K. Scheibe, A. Schmied, C.I. Geppert, B. Schmid, S. Wirtz, O.M. Thoma, V. Kramer, M.J. Waldner, C. Buttner, H.F. Farin, M. Pesic, F. Knieling, S. Merkel, A. Gruneboom, M. Gunzer, R. Grutzmann, S. Rose-John, S.B. Koralov, G. Kollias, M. Vieth, A. Hartmann, F.R. Greten, M.F. Neurath, and C. Neufert.
STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.
Gut 69(7):1269-1282.
doi: 10.1136/gutjnl-2019-319200.

2019

Schmitt, H., C. Neufert, M.F. Neurath, and R. Atreya
Resolution of Crohn´s disease
Seminars in Immunology. 41(6):737-746.
doi: 10.1007/s00281-019-00756-1.

Atreya, I., M. Kindermann, and S. Wirtz.
Innate lymphoid cells in intestinal cancer development.
Seminars in Immunology. 41:101267
doi: 10.1016/j.smim.2019.02.001.

Bacher, P., T. Hohnstein, E. Beerbaum, M. Rocker, M.G. Blango, S. Kaufmann, J. Rohmel, P. Eschenhagen, C. Grehn, K. Seidel, V. Rickerts, L. Lozza, U. Stervbo, M. Nienen, N. Babel, J. Milleck, M. Assenmacher, O.A. Cornely, M. Ziegler, H. Wisplinghoff, G. Heine, M. Worm, B. Siegmund, J. Maul, P. Creutz, C. Tabeling, C. Ruwwe-Glosenkamp, L.E. Sander, C. Knosalla, S. Brunke, B. Hube, O. Kniemeyer, A.A. Brakhage, C. Schwarz, and A. Scheffold.
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.
Cell. 176(6):1340-1355.e15.
doi: 10.1016/j.cell.2019.01.041.

Bardenbacher, M., B. Ruder, N. Britzen-Laurent, B. Schmid, M. Waldner, E. Naschberger, M. Scharl, W. Muller, C. Günther, C. Becker, M. Stürzl, and P. Tripal.
Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.
Stem Cell Research 35:101383.
doi: 10.1016/j.scr.2019.101383.

Bayer, K.E., L. Neeb, A. Bayer, J.J. Wiese, B. Siegmund, and M.S. Prüss.
Reduction of intra-abdominal pain through transcranial direct current stimulation A systematic review.
Medicine
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Delbue, D., D. Cardoso-Silva, F. Branchi, A. Itzlinger, M. Letizia, B. Siegmund, and M. Schumann.
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Dilipkumar, A., A. Al-Shemmary, L. Kreiss, K. Cvecek, B. Carle, F. Knieling, J.G. Menezes, O.M. Thoma, M. Schmidt, M.F. Neurath, M. Waldner, O. Friedrich, and S. Schurmann.
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Finotello, F., C. Mayer, C. Plattner, G. Laschober, D. Rieder, H. Hackl, A. Krogsdam, Z. Loncova, W. Posch, D. Wilflingseder, S. Sopper, M. Ijsselsteijn, T.P. Brouwer, D. Johnson, Y.M. Xu, Y. Wang, M.E. Sanders, M.V. Estrada, P. Ericsson-Gonzalez, P. Charoentong, J. Balko, N. de Miranda, and Z. Trajanoski.
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Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation.
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Gronke, K., P.P. Hernandez, J. Zimmermann, C.S.N. Klose, M. Kofoed-Branzk, F. Guendel, M. Witkowski, C. Tizian, L. Amann, F. Schumacher, H. Glatt, A. Triantafyllopoulou, and A. Diefenbach.
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Günther, C., B. Ruder, I. Stolzer, H. Dorner, G.W. He, M.T. Chiriac, K. Aden, A. Strigli, M. Bittel, S. Zeissig, P. Rosenstiel, R. Atreya, M.F. Neurath, S. Wirtz, and C. Becker.
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Knipfer, L., A. Schulz-Kuhnt, M. Kindermann, V. Greif, C. Symowski, D. Voehringer, M.F. Neurath, I. Atreya, and S. Wirtz. 
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Kredel, L.I., L.J. Jodicke, A. Scheffold, J. Grone, R. Glauben, U. Erben, A.A. Kühl, and B. Siegmund.
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Langer, V., E. Vivi, D. Regensburger, T.H. Winkler, M.J. Waldner, T. Rath, B. Schmid, L. Skottke, S. Lee, N.L. Jeon, T. Wohlfahrt, V. Kramer, P. Tripal, M. Schumann, S. Kersting, C. Handtrack, C.I. Geppert, K. Suchowski, R.H. Adams, C. Becker, A. Ramming, E. Naschberger, N. Britzen-Laurent, and M. Stürzl.
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Leppkes, M., M. Schick, B. Hohberge, A. Mahajan, J. Knopf, G. Schett, L.E. Munoz, and M. Herrmann.
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Lichnog, C., S. Klabunde, E. Becker, F. Fuh, P. Tripal, R. Atreya, E. Klenske, R. Erickson, H. Chiu, C. Reed, S. Chung, C. Neufert, I. Atreya, J. McBride, M.F. Neurath, and S. Zundler.
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Lopez-Posadas, R., P. Fastancz, L.D. Martinez-Sanchez, J. Panteleev-Ivlev, V. Thonn, T. Kisseleva, L.S. Becker, A. Schulz-Kuhnt, S. Zundler, S. Wirtz, R. Atreya, B. Carle, O. Friedrich, S. Schürmann, M.J. Waldner, C. Neufert, C.H. Brakebusch, M.O. Bergo, M.F. Neurath, and I. Atreya.
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Mahajan, A., A. Gruneboom, L. Petru, M.J. Podolska, L. Kling, C. Maueroder, F. Dahms, S. Christiansen, L. Gunter, V. Krenn, A. Junemann, F. Bock, C. Schauer, G. Schett, B. Hohberger, M. Herrmann, and L.E. Munoz.
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Neeb, L., A. Bayer, K.E. Bayer, A. Farmer, J.B. Fiebach, B. Siegmund, and M.S. Volz.
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Scarozza, P., H. Schmitt, G. Monteleone, M.F. Neurath, and R. Atreya.
Oligonucleotides-A Novel Promising Therapeutic Option for IBD.
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Scheibe, K., C. Kersten, A. Schmied, M. Vieth, T. Primbs, B. Carle, F. Knieling, J. Claussen, A.C. Klimowicz, J. Zheng, P. Baum, S. Meyer, S. Schurmann, O. Friedrich, M.J. Waldner, T. Rath, S. Wirtz, G. Kollias, A.B. Ekici, R. Atreya, E.L. Raymond, M.L. Mbow, M.F. Neurath, and C. Neufert. 
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Schellerer, V.S., M.C. Langheinrich, V. Zver, R. Grutzmann, M. Stürzl, O. Gefeller, E. Naschberger, and S. Merkel.
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Schmidt, F., K. Dahlke, A. Batra, J. Keye, H. Wu, M. Friedrich, R. Glauben, C. Ring, G. Loh, M. Schaubeck, H. Hackl, Z. Trajanoski, M. Schumann, A.A. Kühl, M. Blaut, and B. Siegmund.
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Schubart, C., B. Krljanac, M. Otte, C. Symowski, E. Martini, C. Günther, C. Becker, C. Daniel, and D. Voehringer.
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Schulz-Kuhnt, A., S. Zundler, A. Gruneboom, C. Neufert, S. Wirtz, M.F. Neurath, and I. Atreya.
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy.
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Zundler, S., M. Wiendl, and M.F. Neurath.
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Yerinde, C., B. Siegmund, R. Glauben, and C. Weidinger.
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Ziegler, J.F., C. Bettcher, M. Letizia, C. Yerinde, H. Wu, I. Freise, Y. Rodriguez-Sillke, A.K. Stoyanova, M.E. Kreis, P. Asbach, D. Kunkel, J. Priller, I. Anagnostopoulos, A.A. Kühl, K. Miehle, M. Stumvoll, F. Tran, B. Fredrich, M. Forster, A. Franke, C. Bojarski, R. Glauben, B.S. Loscher, B. Siegmund, and C. Weidinger. 
Leptin induces TNF alpha-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease.
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Zundler, S., E. Becker, L.L. Schulze, and M.F. Neurath.
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Zundler, S., E. Becker, M. Spocinska, M. Slawik, L. Parga-Vidal, R. Stark, M. Wiendl, R. Atreya, T. Rath, M. Leppkes, K. Hildner, R. Lopez-Posadas, S. Lukassen, A.B. Ekici, C. Neufert, I. Atreya, K. van Gisbergen, and M.F. Neurath.
Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation.
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Itzlinger A, Branchi F, Elli L, Schumann M.
Gluten-Free Diet in Celiac Disease-Forever and for All?
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Bacher P, Scheffold A.
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Hammer Q, Ruckert T, Romagnani C.
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Jung D, Heiss R, Kramer V, Thoma OM, Regensburger AP, Rascher W, Uder M, Neurath MF, Knieling F, Waldner MJ.
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Leppkes M, Siegmund B, Becker C.
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Rath, T, Billmeier U, Ferrazzi F, Vieth M, Ekici A, Neurath MF, Atreya R.
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Ruder B, Murtadak V, Sturzl M, Wirtz S, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu YL, Neurath MF, Cesarman E, Ballon G, Günther C, Becker C.
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Zundler S, Dietz L, Matzel KE, Geppert CI, Becker E, Rath T, Neurath MF, Atreya R.
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