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Signals mediating crosstalk of intestinal epithelial cells with innate lymphoid cells in inflammatory bowel diseases
Prof. Dr. Chiara Romagnani
Innate lymphoid cells (ILCs) are major regulator of intestinal epithelial cell (IEC) homeostasis and play a dual role in intestinal inflammation. However the mechanisms underlying this phenomenon remain unclear. We postulate that distinct IEC signals can shape ILC effector functions, thereby differentially impacting on epithelium responses and intestinal inflammation. Central focus of this project will be the characterization of signals governing the ILC-IEC crosstalk during homeostasis and inflammation. Identification and manipulation of such pathways will be used to promote IEC regeneration and protective functions, while dampening pathogenic circuits involved in inflammatory bowel disease.