Project Area A
Immune Regulation of Intestinal Barrier Functions
A01
Innate modules of intestinal epithelial cell protection in inflammatory bowel diseases
Prof. Dr. Andreas Diefenbach & Dr. Antigoni Triantafyllopoulou
A02
Mechanisms linking IFN-mediated mixed lineage kinase domain-like protein activation with intestinal inflammation
PD Dr. Claudia Günther
A03
Mucosal type 2 immunity as regulator of epithelial cell functions in inflammatory bowel diseases
Prof. Dr. Christoph Becker & PD Dr. Stefan Wirtz
A04
Microbiota - TLR4 - TNFα axis in control of epithelial tissue functions in IBD
Dr. Andrey Kruglov
A05
Oncostatin M - a novel cytokine in inflammatory bowel diseases pathogenesis
Prof. Dr. Ahmed N. Hegazy
A06
Inflammation-induced intestinal vascular barrier dysfunctions and their impact on the immune-epithelial crosstalk in inflammatory bowel diseases
Prof. Dr. Michael Stürzl & PD Dr. Natalie Britzen-Laurent
A07
Regulation and function of prenylation within intestinal epithelial cells in the context of inflammation
Dr. Imke Atreya & Dr. Rocío López-Posadas
A08
Molecular and functional studies on the crosstalk between induced IELs and IECs in intestinal homeostasis and inflammation
Prof. Dr. Kai Hildner & PD Dr. Clemens Neufert
Project Area B
Epithelium as Modifier of Mucosal Immunity and Inflammation
B01
Mesenteric fat - an immunological barrier in Crohn's disease
Dr. Carl Weidinger & Prof. Dr. Britta Siegmund
B02
Signals mediating crosstalk of intestinal epithelial cells with innate lymphoid cells in inflammatory bowel diseases
Prof. Dr. Chiara Romagnani
B03
The intestinal epithelial cells in the dialogue between microbiota and the immune system
Dr. Hyun-Dong Chang & Prof. Dr. Andreas Radbruch
B04
The emergency barrier function of neutrophil extracellular traps and their interaction with the intestinal epithelium
Prof. Dr. Martin Herrmann & Dr. Moritz Leppkes
B05
Neuropeptides and TRP channels as effectors in colonic epithelial and immune cell function in IBD
Prof. Dr. Christoph Becker & Dr. Jay Patankar
B06
Interplay of the impaired tight junction and the subjacent immune cells in IBD
PD Dr. Susanne M. Krug & Prof. Dr. Jörg-Dieter Schulzke
B07
Identification and functional characterization of human microbiota-specific regulatory T cells
Prof. Dr. Alexander Scheffold
Project Area C
Diagnostics and Therapeutic Intervention
C01
Determining function and dysfunction of the intestinal epithelium using advanced label-free imaging techniques
Prof. Dr. Maximilian Waldner & Dr. Sebastian Schürmann
C02
In vivo endoscopic molecular imaging to predict response to biological therapies in ulcerative colitis
Prof. Dr. Raja Atreya & PD Dr. Christan Bojarski
C03
Transcranial direct current stimulation for chronic, IBD-associated abdominal pain and the relation of pain perception and the intestinal epithelial barrier
Dr. Magdalena Prüß & Dr. Michael Schumann & Prof. Dr. Raja Atreya
C04
A phase II multi-center clinical trial to study efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis
Dr. Caroline Bosch-Voskens & Prof. Dr. Markus F. Neurath
Project Area Z
IBDome
Prof. Dr. Raja Atreya & Prof. Dr. Zlatko Trajanoski & PD Dr. Anja A. Kühl
Integrated Research Training Group
Dr. Imke Atreya & Prof. Dr. Chiara Romagnani
Project Management and Administration
Prof. Dr. Christoph Becker & Prof. Dr. Britta Siegmund