Project Area A
Immune Regulation of Intestinal Barrier Functions
![Prof. Dr. Andreas Diefenbach](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/prof-dr-andreas-diefenbach.jpg)
![Dr. Antigoni Triantafyllopoulou](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/dr-antigoni-triantafyllopoulou.jpg)
A01
Innate modules of intestinal epithelial cell protection in inflammatory bowel diseases
Prof. Dr. Andreas Diefenbach & Dr. Antigoni Triantafyllopoulou
![PD Dr. Claudia Günther](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/pd-dr-claudia-guenther.jpg)
A02
Mechanisms linking IFN-mediated mixed lineage kinase domain-like protein activation with intestinal inflammation
PD Dr. Claudia Günther
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Christoph-Becker-2020web1.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Wirtz-angepasst.jpg)
A03
Mucosal type 2 immunity as regulator of epithelial cell functions in inflammatory bowel diseases
Prof. Dr. Christoph Becker & PD Dr. Stefan Wirtz
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Kruglov-2.jpg)
A04
Microbiota - TLR4 - TNFα axis in control of epithelial tissue functions in IBD
Dr. Andrey Kruglov
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Hegazy-2.jpg)
A05
Oncostatin M - a novel cytokine in inflammatory bowel diseases pathogenesis
Prof. Dr. Ahmed N. Hegazy
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Stürzl-angepasst.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Britzen-Laurent-angepasst.jpg)
A06
Inflammation-induced intestinal vascular barrier dysfunctions and their impact on the immune-epithelial crosstalk in inflammatory bowel diseases
Prof. Dr. Michael Stürzl & PD Dr. Natalie Britzen-Laurent
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Atreya-Imke.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Lopez-Posadas.jpg)
A07
Regulation and function of prenylation within intestinal epithelial cells in the context of inflammation
Dr. Imke Atreya & Dr. Rocío López-Posadas
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Hildner.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Neufert.jpg)
A08
Molecular and functional studies on the crosstalk between induced IELs and IECs in intestinal homeostasis and inflammation
Prof. Dr. Kai Hildner & PD Dr. Clemens Neufert
Project Area B
Epithelium as Modifier of Mucosal Immunity and Inflammation
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Carl-Weidinger.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Siegmund.jpg)
B01
Mesenteric fat - an immunological barrier in Crohn's disease
Dr. Carl Weidinger & Prof. Dr. Britta Siegmund
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Romagnani.jpg)
B02
Signals mediating crosstalk of intestinal epithelial cells with innate lymphoid cells in inflammatory bowel diseases
Prof. Dr. Chiara Romagnani
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Chang-1.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Radbruch.jpg)
B03
The intestinal epithelial cells in the dialogue between microbiota and the immune system
Dr. Hyun-Dong Chang & Prof. Dr. Andreas Radbruch
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Herrmann.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Leppkes.jpg)
B04
The emergency barrier function of neutrophil extracellular traps and their interaction with the intestinal epithelium
Prof. Dr. Martin Herrmann & Dr. Moritz Leppkes
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Christoph-Becker-2020web1.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Dr.-Jay-V.-Patankar.jpg)
B05
Neuropeptides and TRP channels as effectors in colonic epithelial and immune cell function in IBD
Prof. Dr. Christoph Becker & Dr. Jay Patankar
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Krug-002.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Schulzke-1.jpg)
B06
Interplay of the impaired tight junction and the subjacent immune cells in IBD
PD Dr. Susanne M. Krug & Prof. Dr. Jörg-Dieter Schulzke
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/AlexanderScheffold.jpg)
B07
Identification and functional characterization of human microbiota-specific regulatory T cells
Prof. Dr. Alexander Scheffold
Project Area C
Diagnostics and Therapeutic Intervention
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Waldner.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Sebastian.jpg)
C01
Determining function and dysfunction of the intestinal epithelium using advanced label-free imaging techniques
Prof. Dr. Maximilian Waldner & Dr. Sebastian Schürmann
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Prof.-Atreya.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Bojarski-1.jpg)
C02
In vivo endoscopic molecular imaging to predict response to biological therapies in ulcerative colitis
Prof. Dr. Raja Atreya & PD Dr. Christan Bojarski
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Foto_MP.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Schumann-297.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Prof.-Atreya.jpg)
C03
Transcranial direct current stimulation for chronic, IBD-associated abdominal pain and the relation of pain perception and the intestinal epithelial barrier
Dr. Magdalena Prüß & Dr. Michael Schumann & Prof. Dr. Raja Atreya
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/csm_21_DE_Bosch-Voskens_presse_728eaf6e00.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Neurath-1.jpg)
C04
A phase II multi-center clinical trial to study efficacy and in vivo trafficking of autologous adoptively transferred ex vivo expanded regulatory T cells in patients with ulcerative colitis
Dr. Caroline Bosch-Voskens & Prof. Dr. Markus F. Neurath
Project Area Z
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Prof.-Atreya.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Trajanoski_13032018_florianlechner.com_324A5272-002.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Kühl-1.jpg)
IBDome
Prof. Dr. Raja Atreya & Prof. Dr. Zlatko Trajanoski & PD Dr. Anja A. Kühl
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Atreya-Imke.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Romagnani.jpg)
Integrated Research Training Group
Dr. Imke Atreya & Prof. Dr. Chiara Romagnani
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Christoph-Becker-2020web1.jpg)
![](https://transregio241-en.webspace.rrze.de/wp-content/uploads/2020/01/Siegmund.jpg)
Project Management and Administration
Prof. Dr. Christoph Becker & Prof. Dr. Britta Siegmund